Overhauser-enhanced MRI as a non invasive probe of BBB breakdown and redox state following ischemia/reperfusion
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چکیده
Overhauser-enhanced MRI as a non invasive probe of BBB breakdown and redox state following ischemia/reperfusion Matthew S. Rosen, Mathieu Sarracanie, Brandon D. Armstrong, Fanny Herisson, Najat Salameh, and Cenk Ayata Department of Radiology, MGH/Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States, Department of Physics, Harvard University, Cambridge, MA, United States, Department of Radiology, MGH/Neurovascular Research Lab, Charlestown, MA, United States, Department of Radiology, Harvard Medical School, Boston, MA, United States, Institut de Physique des Systèmes Biologiques, EPFL, Lausanne, Vaud, Switzerland
منابع مشابه
ارزیابی تأثیر مهار تولید نیتریک اکساید توسط L-NAME بر میزان نفوذپذیری سد خونی-مغزی و نسخهبرداری ژنهای کلودین-3 و 12 در نواحی زیر قشری به دنبال ایسکمی-خونرسانی مجدد مغزی در موش صحرایی نر
Background & Aims: Blood-brain barrier (BBB) breakdown and nitric oxide (NO) overproduction following cerebral ischemia-reperfusion extensively happens in the subcortical regions (core areas). Hence, we assessed the effects of NO inhibition by L-NAME on transcription of the transmembrane proteins claudin-3 and 12, with key role in BBB structure, at subcortical areas following cerebral ischemia-...
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